I have this same exact issue on Windows machines. The guidance for adding split tunneling via IP addresses have been done as well.
On Windows, we are experiencing the same exact issue where when we connect to VPN, the Netskope agent goes red and then a disconnect/reconnect fixes the issue for a period of time. It's very intermittent. I have a ticket opened with Netskope Support but no clear fix.
GP Version: 5.2.6