For the Manual client on either Mac or Windows, I would recommend performing the email invite.
With regards to the anti-virus exclusions, the Netskope client doesn't confirm if exclusions are in place. So I would recommend, checking the anti-virus logs to validate none of the Netskope locations that are documented in https://docs.netskope.com/en/exceptions-for-anti-virus-applications.html have been subject to a scan (both real-time or scheduled).
The Netskope document, https://docs.netskope.com/en/exceptions-for-anti-virus-applications.html, describes what Netskope folders and files to configure in the exclusion in the A/V admin console.
The A/V should have some way to confirm that the exclusions are in place. As an example, here is one I found for MS Defender, the steps to confirm are listed at the end of the document. - https://learn.microsoft.com/en-us/microsoft-365/security/defender-endpoint/configure-extension-file-...
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